B o n iv a ^ L

IMPORTANT FACTS ABOUT BONIVA

Ibandronate sodium

(b o n -E E -v a) ib a n d ro n a te so d iu m 150-m g tab let

BONIVA, a bisphosphonate, is a prescription medicine used to treat and prevent osteoporosis in

postmenopausal women, characterized by weakening of the bone.

Taken once a month in tablet form, BONIVA may stop and reverse hone loss in most women.

It has been clinically proven to help build and maintain bone density, which can help reduce fractures.

What is the most important information about BONIVA?

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BONIVA may cause serious problems in the stomach and the esophagus (the tube that connects your mouth and stomach) such as trouble swallowing, heartburn, and ulcers,

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Before you start BONIVA.

Tell your health care provider if you:

• are pregnant or plan to become pregnant

• are breast-feeding

• have trouble swallowing or other problems with your esophagus

• have kidney problems

• are planning a dental procedure such as tooth extraction

Tell your health care provider and dentist about all medications

you're taking, including vitamins, antacids, and supplements.

Who should not take BONIVA?

Do not take BONIVA if you:

• have abnormalities with your esophagus, such as

restriction or difficulty swallowing

• have low blood calcium (hypocalcemia)

• cannot sit or stand for at least 60 minutes

• have kidneys that work very poorly

• are allergic to BONIVA or any of its ingredients

See Patient Information for complete list.

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W hat is BONIVA?

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G e n e n t e c h

A Member of the Roche Group